Assistant Professor of Bioinformatics
B.A., New College of Florida
Professor Ryba is a computational biologist with interests in epigenetic regulation and applying computational methods to study the biology of human disease. His research examines relationships between genome structure and function, with a focus on large-scale domain regulation and misregulation in respiratory disorders and pediatric leukemia. He enjoys teaching the theory and practice of deriving information from biological data, and participating in related ISPs, tutorials, and collaborative projects.
Pope, B.D., Ryba, T., Dileep, V., Yue, F., Wu, W., Denas, O., Vera, D.L., Wang, Y., Hansen, R.S., Canfield, T.K., Thurman, R.E., Cheng, Y., Gülsoy, G., Dennis, J.H., Snyder, M.P., Stamatoyannopoulos, J.A., Taylor, J., Hardison, R.C., Kahveci, T., Ren, B., Gilbert, D.M. (2014) Topologically associating domains are stable units of replication-timing regulation. Nature 515: 402–405.
Mouse ENCODE Consortium. (2014) A comparative encyclopedia of DNA elements in the mouse genome. Nature 515: 355–364.
Takebayashi, S., Lei, I., Ryba, T., Sasaki, T., Dileep, V., Battaglia, D., Gao, X., Fang, P., Fan, Y., Esteban, M.A., Tang, J., Crabtree, G.R., Wang, Z., Gilbert, D.M. (2013) Murine esBAF chromatin remodeling complex subunits BAF250a and Brg1 are necessary to maintain and reprogram pluripotency-specific replication timing of select replication domains. Epigenetics & Chromatin 6: 42.
Ryba, T., Battaglia, D., Chang, B.H., Shirley, J.W., Buckley, Q., Pope, B.D., Devidas, M., Druker, B.J., and Gilbert, D.M. (2012) Abnormal developmental control of replication timing domains in pediatric acute lymphoblastic leukemia. Genome Research 22(10): 1833-1844.